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Oryzias latipes, Japanese medaka

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Taxonomy

cellular organisms - Eukaryota - Fungi/Metazoa group - Metazoa - Eumetazoa - Bilateria - Coelomata - Deuterostomia - Chordata - Craniata - Vertebrata - Gnathostomata - Teleostomi - Euteleostomi - Actinopterygii - Actinopteri - Neopterygii - Teleostei - Elopocephala - Clupeocephala - Euteleostei - Neognathi - Neoteleostei - Eurypterygii - Ctenosquamata - Acanthomorpha - Euacanthomorpha - Holacanthopterygii - Acanthopterygii - Euacanthopterygii - Percomorpha - Smegmamorpha - Atherinomorpha - Beloniformes - Adrianichthyoidei - Adrianichthyidae - Oryziinae - Oryzias - Oryzias latipes

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Brief facts

The potential of medaka as a genetic model

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Developmental stages

Life Cycle Stages

Under laboratory conditions, generation time is between 6 and 8 weeks for medaka, compared with 8 and 10 weeks for zebrafish.

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Appendix I: medaka gene knockouts

Taniguchi Y, Takeda S, Furutani-Seiki M, Kamei Y, Todo T, Sasado T, Deguchi T, Kondoh H, Mudde J, Yamazoe M, Hidaka M, Mitani H, Toyoda A, Sakaki Y, Plasterk RH, Cuppen E. Generation of medaka gene knockout models by target-selected mutagenesis. Genome Biol. 2006;7(12):R116. PMID: 17156454

Tumors im medaka p53 knockouts

Various tumors that developed spontaneously in p53 medaka knockouts. (a,b) The tumor that arose in the left gill of a p53E241X/+ fish with the lymphomatous infiltrate, consistent with the diagnosis of thymic lymphoma. (c,d) Adenocarcinoma found in the right gill of a p53E241X/E241X homozygous fish. (e,f) Retinoblastoma in the right eye of a p53E241X/E241X homozygous fish. Note the rosette-like structures throughout the tumor. (g,h) A germ cell tumor found in the anterior upper part of the peritoneal cavity of a p53E241X/E241X homozygous fish. All fish presented here died or were sacrificed at around 8 months of age. Arrowheads indicate tumors. Hematoxylin-eosin staining, original magnification: (b,d) 100x; (f,h) 10x.

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References

Websites and other references

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